Title : Dexmedetomidine attenuates pancreatic injury and inflammatory response in mice with pancreatitis by possible reduction of NLRP3 activation and up-regulation of NET expression.

Pub. Date : 2018 Jan 22

PMID : 29269298






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1 RESULTS: Dexmedetomidine at 20 mug/kg significantly attenuated pancreatic pathological injury, reduced serum levels of amylase, lipase, IL-1beta, IL-6, and tumor necrosis factor (TNF)-alpha, and decreased the expression of MPO in pancreatic tissue in both mouse models of pancreatitis. Dexmedetomidine tumor necrosis factor Mus musculus