Pub. Date : 2018 Mar 1
PMID : 29259012
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | FIH Is an Oxygen Sensor in Ovarian Cancer for G9a/GLP-Driven Epigenetic Regulation of Metastasis-Related Genes. | Oxygen | euchromatic histone lysine methyltransferase 2 | Homo sapiens |
| 2 | Here, we show that FIH exerts an additional role as an oxygen sensor in epigenetic control by the histone lysine methyltransferases G9a and GLP. | Oxygen | euchromatic histone lysine methyltransferase 2 | Homo sapiens |
| 3 | It also implies that the FIH-G9a/GLP pathway could be a potential target for inhibiting hypoxia-induced cancer metastasis.Significance: These findings deepen understanding of oxygen-dependent gene regulation and cancer metastasis in response to hypoxia. | Oxygen | euchromatic histone lysine methyltransferase 2 | Homo sapiens |