Title : The protective effect of umbelliferone ameliorates myocardial injury following ischemia‑reperfusion in the rat through suppression NLRP3 inflammasome and upregulating the PPAR-γ.

Pub. Date : 2018 Feb

PMID : 29257247






1 Functional Relationships(s)
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1 Compared with the myocardial injury following ischemia-reperfusion group, umbelliferone significantly prevented myocardial injury, inhibited oxidative stress markers (superoxide dismutase and malondialdehyde), reduced inflammation (tumor necrosis factor-alpha and interleukin-6) and myocardial apoptosis levels (caspase-3/9 and apoptosis regular B-cell lymphoma-2-associated X protein) in the myocardial injury following ischemia-reperfusion group of rats. 7-hydroxycoumarin caspase 3 Rattus norvegicus