Title : Genetic variation in TNFα, PPARγ, and IRS-1 genes, and their association with breast-cancer survival in the HEAL cohort.

Pub. Date : 2018 Apr

PMID : 29256014






1 Functional Relationships(s)
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1 RESULTS: Carriers of the PPARgamma variant allele had statistically significantly lower rates of type 2 diabetes (P = 0.04), lower BMI (P = 0.01), and HOMA scores [P = 0.004; non-Hispanic White (NHWs) only]; carriers of the TNF-alpha variant A allele had higher serum glucose (P = 0.004, NHW only); and the IRS-1 variant was associated with higher leptin levels (P = 0.003, Hispanics only). Glucose peroxisome proliferator activated receptor gamma Homo sapiens