Title : Relation of urinary endothelin-1 to stress-induced pressure natriuresis in healthy adolescents.

Pub. Date : 2018 Jan

PMID : 29246686






4 Functional Relationships(s)
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1 Our preclinical studies demonstrate an important role for renal endothelin-1 (ET-1) in regulating sodium excretion. Sodium endothelin 1 Homo sapiens
2 Our preclinical studies demonstrate an important role for renal endothelin-1 (ET-1) in regulating sodium excretion. Sodium endothelin 1 Homo sapiens
3 We hypothesize that reduced renal ET-1 accounts for derangements in sodium handling under stress, a link never explored in a large human cohort. Sodium endothelin 1 Homo sapiens
4 Thus, loss of ET-1-dependent natriuresis may account for sodium retention during stress and may predispose retainers to renal diseases such as hypertension and kidney disease. Sodium endothelin 1 Homo sapiens