Pub. Date : 2018 Feb
PMID : 29241031
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The protective effect of dexmedetomidine on LPS-induced acute lung injury through the HMGB1-mediated TLR4/NF-kappaB and PI3K/Akt/mTOR pathways. | Dexmedetomidine | nuclear factor kappa B subunit 1 | Homo sapiens |
| 2 | Additionally, treatment with DEX inhibited the expression of HMGB1, TLR4, MyD88, p-IkappaB, p-NF-kappaB, p-PI3K, p-Akt and p-mTOR in vivo and in vitro. | Dexmedetomidine | nuclear factor kappa B subunit 1 | Homo sapiens |
| 3 | In conclusion, the present study showed that DEX exerted a protective effect on LPS-induced ALI rats likely through the HMGB1-mediated TLR4/NF-kappaB and PI3K/Akt/mTOR pathways. | Dexmedetomidine | nuclear factor kappa B subunit 1 | Homo sapiens |