Title : Anti-inflammatory activity of anti-hyperlipidemic drug, fenofibrate, and its phase-I metabolite fenofibric acid: in silico, in vitro, and in vivo studies.

Pub. Date : 2018 Aug

PMID : 29238904






1 Functional Relationships(s)
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1 The test compounds fenofibric acid, fenofibrate, and the standard drug diclofenac exhibited binding energies of - 9.0, - 7.2, and - 8.0 kcal mol-1, respectively, against COX-2 and - 7.2, - 7.0, and - 6.5 kcal mol-1, respectively, against COX-1. fenofibric acid mitochondrially encoded cytochrome c oxidase I Homo sapiens