Title : Indole-3-propionic acid suppresses indoxyl sulfate-induced expression of fibrotic and inflammatory genes in proximal tubular cells.

Pub. Date : 2017 Nov

PMID : 29238104






3 Functional Relationships(s)
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1 We determined whether IPA suppresses IS-induced expression of AHR, CYP1A1, TGF-beta1, and MCP-1 in proximal tubular cells. ipa chemokine (C-C motif) ligand 2 Mus musculus
2 IPA significantly suppressed IS-induced mRNA and protein expression of AHR, CYP1A1, TGF-beta1, and MCP-1 in HK-2 cells. ipa chemokine (C-C motif) ligand 2 Mus musculus
3 In conclusion, IPA suppressed the IS-induced expression of AHR, CYP1A1, TGF-beta1, and MCP-1 through suppression of Stat3 in proximal tubular cells. ipa chemokine (C-C motif) ligand 2 Mus musculus