Title : mPGES1-Dependent Prostaglandin E2 (PGE2) Controls Antigen-Specific Th17 and Th1 Responses by Regulating T Autocrine and Paracrine PGE2 Production.

Pub. Date : 2018 Jan 15

PMID : 29237778






2 Functional Relationships(s)
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1 However, in contrast with CD4+ cells that were Ag primed in vivo, exogenous PGE2 inhibited proliferation and skewed IL-17A to IFN-gamma production under Th17 polarization of naive T cells in vitro. Dinoprostone interferon gamma Homo sapiens
2 Furthermore, we uncover a coordination of autocrine and paracrine mPGES1-driven PGE2 production that impacts effector T cell IL-17A and IFN-gamma responses. Dinoprostone interferon gamma Homo sapiens