Pub. Date : 2017
PMID : 29225516
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Hedgehog/Gli1 signaling pathway regulates MGMT expression and chemoresistance to temozolomide in human glioblastoma. | Temozolomide | GLI family zinc finger 1 | Homo sapiens |
| 2 | This study is to determine the relationship between Hedgehog (HH)/Gli1 signaling pathway and chemoresistance to temozolomide (TMZ) in human GBM. | Temozolomide | GLI family zinc finger 1 | Homo sapiens |
| 3 | This study is to determine the relationship between Hedgehog (HH)/Gli1 signaling pathway and chemoresistance to temozolomide (TMZ) in human GBM. | Temozolomide | GLI family zinc finger 1 | Homo sapiens |
| 4 | Quantitative PCR, western blot, methylation-specific PCR, cell proliferation and apoptosis assay were used to investigate changes of MGMT expression and chemosensitivity to TMZ after manipulating HH/Gli1 signaling activity in A172 and U251 GBM cell lines. | Temozolomide | GLI family zinc finger 1 | Homo sapiens |
| 5 | Activation of HH/Gli1 signaling by pcDNA3.1-Gli1 cell transfection in A172 cells led to increased MGMT expression and enhanced resistance to TMZ treatment. | Temozolomide | GLI family zinc finger 1 | Homo sapiens |
| 6 | Activation of HH/Gli1 signaling by pcDNA3.1-Gli1 cell transfection in A172 cells led to increased MGMT expression and enhanced resistance to TMZ treatment. | Temozolomide | GLI family zinc finger 1 | Homo sapiens |
| 7 | Inhibition of the HH/Gli1 signaling by cyclopamine in U251 cells resulted in decreased MGMT expression and increased sensitivity to TMZ treatment. | Temozolomide | GLI family zinc finger 1 | Homo sapiens |
| 8 | Conclusions: This study shows that HH/Gli1 signaling pathway regulates MGMT expression and chemoresistance to TMZ in human GBM independent from MGMT promoter methylation status, which offers a potential target to restore chemosensitivity to TMZ in a fraction of GBM with high MGMT expression. | Temozolomide | GLI family zinc finger 1 | Homo sapiens |
| 9 | Conclusions: This study shows that HH/Gli1 signaling pathway regulates MGMT expression and chemoresistance to TMZ in human GBM independent from MGMT promoter methylation status, which offers a potential target to restore chemosensitivity to TMZ in a fraction of GBM with high MGMT expression. | Temozolomide | GLI family zinc finger 1 | Homo sapiens |