Title : CNB-001, a synthetic pyrazole derivative of curcumin, suppresses lipopolysaccharide-induced nitric oxide production through the inhibition of NF-κB and p38 MAPK pathways in microglia.

Pub. Date : 2018 Jan 15

PMID : 29221948






1 Functional Relationships(s)
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1 In primary cultured rat microglia, CNB-001 (1-10microM) suppressed the lipopolysaccharide (LPS)-induced nitric oxide (NO) production and expression of inducible NO synthase (iNOS), and the potency of CNB-001 was stronger than curcumin. Curcumin nitric oxide synthase 2 Rattus norvegicus