Title : Clinical and neuropathological features of ALS/FTD with TIA1 mutations.

Pub. Date : 2017 Dec 7

PMID : 29216908






1 Functional Relationships(s)
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1 Detailed evaluation of the pyramidal motor system found a similar degree of neurodegeneration and TDP-43 pathology as in sALS and C9orf72+ cases; however, cases with TIA1 mutations had increased numbers of lower motor neurons containing round eosinophilic and Lewy body-like inclusions on HE stain and round compact cytoplasmic inclusions with TDP-43 immunohistochemistry. Helium TIA1 cytotoxic granule associated RNA binding protein Homo sapiens