Pub. Date : 2017 Dec 6
PMID : 29212711
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We documented that the PPARdelta agonist KD3010 is an effective therapy for HD in a mouse model. | 4-(2,6-dimethyl-4-(4-trifluoromethoxyphenyl)piperazine-1-sulfonyl)indan-2-carboxylic acid | peroxisome proliferator activator receptor delta | Mus musculus |
| 2 | To determine the basis for PPARdelta neuroprotection, we evaluated metabolic function and noted markedly impaired oxidative metabolism in HD neurons, which was rescued by bexarotene or KD3010. | 4-(2,6-dimethyl-4-(4-trifluoromethoxyphenyl)piperazine-1-sulfonyl)indan-2-carboxylic acid | peroxisome proliferator activator receptor delta | Mus musculus |