Title : Opioid-induced inhibition of the human 5-HT and noradrenaline transporters in vitro: link to clinical reports of serotonin syndrome.

Pub. Date : 2018 Feb

PMID : 29210063






2 Functional Relationships(s)
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1 KEY RESULTS: Dextromethorphan, l(R)-methadone, racemic methadone, pethidine, tramadol and tapentadol inhibited the SERT at or close to observed drug plasma or estimated brain concentrations in patients. Methadone solute carrier family 6 member 4 Homo sapiens
2 SERT inhibition by tramadol, tapentadol, methadone, dextromethorphan and pethidine may contribute to the serotonin syndrome. Methadone solute carrier family 6 member 4 Homo sapiens