Title : PKM2 activation sensitizes cancer cells to growth inhibition by 2-deoxy-D-glucose.

Pub. Date : 2017 Oct 31

PMID : 29207616






2 Functional Relationships(s)
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1 We demonstrate that TEPP-46, a PKM2 activator, results in increased glucose consumption, providing the rationale for combining PKM2 activators with the toxic glucose analog, 2-deoxy-D-glucose (2-DG). TEPP-46 pyruvate kinase M1/2 Homo sapiens
2 We demonstrate that TEPP-46, a PKM2 activator, results in increased glucose consumption, providing the rationale for combining PKM2 activators with the toxic glucose analog, 2-deoxy-D-glucose (2-DG). TEPP-46 pyruvate kinase M1/2 Homo sapiens