Protein Name pyruvate kinase M1/2
Organism Homo sapiens
Gene ID 5315
Gene Symbol


UniProt P14618 (KPYM_HUMAN), B4DNK4 (B4DNK4_HUMAN), V9HWB8 (V9HWB8_HUMAN), A0A024R5Z9 (A0A024R5Z9_HUMAN)
Relationships Total Number of functionally related compound(s) : 441
Total Number of Articles : 624

pyruvate kinase M1/2

Gene Summary

This gene encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. Several alternatively spliced transcript variants encoding a few distinct isoforms have been reported. [provided by RefSeq, May 2011]

  • pyruvate kinase PKM
  • OPA-interacting protein 3
  • PK, muscle type
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