Pub. Date : 2018 Feb
PMID : 29197117
1 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Coupled with the fact that certain thiopurine metabolites, notably 6-thioguanine nucleotide and 6-methylmercaptopurine, are associated with antiinflammatory effects and adverse effects, respectively, some investigators have examined intentionally shunting the metabolism of azathioprine toward increasing 6-thioguanine nucleotide levels by using low doses of the xanthine oxidoreductase inhibitor allopurinol to improve efficacy and decrease toxicity of azathioprine in patients with inflammatory bowel disease. | 2-mercaptopyrazine | xanthine dehydrogenase | Homo sapiens |