Protein Name xanthine dehydrogenase
Organism Homo sapiens
Gene ID 7498
Gene Symbol


UniProt P47989 (XDH_HUMAN)
Relationships Total Number of functionally related compound(s) : 285
Total Number of Articles : 460

xanthine dehydrogenase

Gene Summary

Xanthine dehydrogenase belongs to the group of molybdenum-containing hydroxylases involved in the oxidative metabolism of purines. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Xanthine dehydrogenase can be converted to xanthine oxidase by reversible sulfhydryl oxidation or by irreversible proteolytic modification. Defects in xanthine dehydrogenase cause xanthinuria, may contribute to adult respiratory stress syndrome, and may potentiate influenza infection through an oxygen metabolite-dependent mechanism. [provided by RefSeq, Jan 2014]

  • xanthine dehydrogenase/oxidase
  • xanthine oxidoreductase
  • XAN1
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