Title : Effect of non-prohibited drugs on the phase II metabolic profile of morphine. An in vitro investigation for doping control purposes.

Pub. Date : 2018 Jun

PMID : 29172026






1 Functional Relationships(s)
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1 A reduction of the enzymatic activity of the UGT2B7 was recorded in the presence of 9 of the 14 drugs under investigation (ketoconazole, miconazole, itraconazole, diclofenac, ibuprofen, clonazepam, lorazepam, lormetazepam, and triazolam), with a consequent significant reduction of the levels of the glucuronide metabolites. Glucuronides UDP glucuronosyltransferase family 2 member B7 Homo sapiens