Title : Association between effectiveness of tuberculosis treatment and cytochrome P-4502E1 polymorphism of the patients.

Pub. Date : 2017 Oct-Dec

PMID : 29171455






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Corresponding of CYP2E1 polymorphism in TB patients with the level of isoniazid and rifampicin as well as for the outcome and toxicity development during inpatient TB treatment. Rifampin cytochrome P450 family 2 subfamily E member 1 Homo sapiens
2 RESULTS: The concentration of rifampicin 6 h after its intake was 17.6% higher in carriers of slow metabolizer (SM) CYP2E1 genotype than in patients with rapid metabolizer (RM) genotype that proved a participation of hepatic enzyme CYP2E1 in metabolism of rifampicin. Rifampin cytochrome P450 family 2 subfamily E member 1 Homo sapiens
3 RESULTS: The concentration of rifampicin 6 h after its intake was 17.6% higher in carriers of slow metabolizer (SM) CYP2E1 genotype than in patients with rapid metabolizer (RM) genotype that proved a participation of hepatic enzyme CYP2E1 in metabolism of rifampicin. Rifampin cytochrome P450 family 2 subfamily E member 1 Homo sapiens