Pub. Date : 2017 Nov 30
PMID : 29168506
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Consistent with a role in surviving the high oxygen environment of incipient lung tumours, NFS1 lies in a region of genomic amplification present in lung adenocarcinoma and is most highly expressed in well-differentiated adenocarcinomas. | Oxygen | NFS1 cysteine desulfurase | Homo sapiens |
| 2 | Above the 3-8% oxygen concentration typical of most tissues, we find that cancer cells depend on high levels of the iron-sulfur cluster biosynthetic enzyme NFS1. | Oxygen | NFS1 cysteine desulfurase | Homo sapiens |
| 3 | NFS1 activity is particularly important for maintaining the iron-sulfur co-factors present in multiple cell-essential proteins upon exposure to oxygen compared to other forms of oxidative damage. | Oxygen | NFS1 cysteine desulfurase | Homo sapiens |