Title : Inhibition of Cytosolic Phospholipase A2α Impairs an Early Step of Coronavirus Replication in Cell Culture.

Pub. Date : 2018 Feb 15

PMID : 29167338






1 Functional Relationships(s)
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1 We obtained evidence to show that a cellular phospholipase, cPLA2alpha, which releases fatty acid from the sn-2 position of membrane-associated glycerophospholipids, is critically involved in coronavirus replication, most likely by producing lysophospholipids that are required to form the specialized membrane compartments in which viral RNA synthesis takes place. Fatty Acids phospholipase A2 group IVA Homo sapiens