Protein Name phospholipase A2 group IVA
Organism Homo sapiens
Gene ID 5321
Gene Symbol


UniProt P47712 (PA24A_HUMAN), B4DZI4 (B4DZI4_HUMAN)
Relationships Total Number of functionally related compound(s) : 664
Total Number of Articles : 1015

phospholipase A2 group IVA

Gene Summary

This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]

  • cytosolic phospholipase A2
  • calcium-dependent phospholipid-binding protein
  • lysophospholipase
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