Title : Andrographolide inhibits hypoxia-induced hypoxia-inducible factor 1α and endothelin 1 expression through the heme oxygenase 1/CO/cGMP/MKP-5 pathways in EA.hy926 cells.

Pub. Date : 2018 Mar

PMID : 29165873






1 Functional Relationships(s)
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1 Concomitantly, the HO-1 byproduct CO and the cGMP analogue 8-bromoguanosine 3",5"-cyclic monophosphate (8-Br-cGMP) increased MKP-5 expression, and pretreatment with CO and 8-Br-cGMP inhibited hypoxia-induced HIF-1alpha and ET-1 expression. 8-bromoguanosino-3',5'-cyclic monophosphorothioate endothelin 1 Homo sapiens