Title : Acute Amino Acid d-Serine Administration, Similar to Ketamine, Produces Antidepressant-like Effects through Identical Mechanisms.

Pub. Date : 2017 Dec 13

PMID : 29161812






1 Functional Relationships(s)
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1 Furthermore, in addition to the increased protein kinase A phosphorylation of the AMPAR subunit GluR1 (an indicator of AMPAR insertion in neurons), treatment with individual optimal doses of d-serine and ketamine also increased adaptin beta2-NMDAR association (an indicator of the intracellular endocytic machinery and subsequent internalization of NMDARs). Ketamine glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus