Title : Curcumin Enhances the Anticancer Effect Of 5-fluorouracil against Gastric Cancer through Down-Regulation of COX-2 and NF- κB Signaling Pathways.

Pub. Date : 2017

PMID : 29151957






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Furthermore, the protein expressions of COX-2 and NF-kappaB in MKN45 cells were decreased by 44.79% and 37.67%, 47.17% and 48.21%, 60.21% and 62.44%, respectively, after treatment of curcumin (25 mumol/l) and 5-FU (50 mumol/l) alone or in combination for 48 h. Curcumin also enhanced the anticancer activity of 5-FU without increasing toxicity in nude mice bearing MKN45 tumor xenografts in vivo. Fluorouracil nuclear factor kappa B subunit 1 Homo sapiens
2 Furthermore, the protein expressions of COX-2 and NF-kappaB in MKN45 cells were decreased by 44.79% and 37.67%, 47.17% and 48.21%, 60.21% and 62.44%, respectively, after treatment of curcumin (25 mumol/l) and 5-FU (50 mumol/l) alone or in combination for 48 h. Curcumin also enhanced the anticancer activity of 5-FU without increasing toxicity in nude mice bearing MKN45 tumor xenografts in vivo. Fluorouracil nuclear factor kappa B subunit 1 Homo sapiens