Pub. Date : 2017 Dec
PMID : 29151909
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | BKM120 sensitizes C6 glioma cells to temozolomide via suppression of the PI3K/Akt/NF-kappaB/MGMT signaling pathway. | NVP-BKM120 | nuclear factor kappa B subunit 1 | Homo sapiens |
| 2 | However, a low concentration of BKM120 inhibited the PI3K/Akt/NF-kappaB signaling pathway activity in glioma cells and significantly increased TMZ cytotoxicity. | NVP-BKM120 | nuclear factor kappa B subunit 1 | Homo sapiens |
| 3 | The reduction of NF-kappaB p65 in combination treatment supported the hypothesis that BKM120 may mediate MGMT transcription via inhibition of NF-kappaB p65. | NVP-BKM120 | nuclear factor kappa B subunit 1 | Homo sapiens |
| 4 | The reduction of NF-kappaB p65 in combination treatment supported the hypothesis that BKM120 may mediate MGMT transcription via inhibition of NF-kappaB p65. | NVP-BKM120 | nuclear factor kappa B subunit 1 | Homo sapiens |
| 5 | The BKM120-induced NF-kappaB p65 inhibition may be involved in the mediation of MGMT transcription to reverse TMZ-resistance in C6 glioma cells. | NVP-BKM120 | nuclear factor kappa B subunit 1 | Homo sapiens |