Pub. Date : 2018 Jan 5
PMID : 29150445
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The antiapoptotic protein HAX-1 (HS-associated protein X-1) localizes to sarcoplasmic reticulum (SR) in the heart and interacts with the small membrane protein phospholamban (PLN), inhibiting the cardiac sarco/endoplasmic reticulum calcium ATPase 2a (SERCA2a) in the regulation of overall calcium handling and heart muscle contractility. | Calcium | phospholamban | Mus musculus |
| 2 | However, because global HAX-1 deletion causes early lethality, how much endogenous HAX-1 contributes to PLN"s inhibitory activity on calcium cycling is unknown. | Calcium | phospholamban | Mus musculus |
| 3 | The enhanced calcium cycling in the HAX-1-depleted heart was mediated through increases in the calcium affinity of SERCA2a and reduced PLN-SERCA2a binding. | Calcium | phospholamban | Mus musculus |