Title : Metformin protects against intestinal barrier dysfunction via AMPKα1-dependent inhibition of JNK signalling activation.

Pub. Date : 2018 Jan

PMID : 29148173






1 Functional Relationships(s)
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1 We showed that metformin alleviated dextran sodium sulphate (DSS)-induced decreases in transepithelial electrical resistance, FITC-dextran hyperpermeability, loss of the tight junction (TJ) proteins occludin and ZO-1 and bacterial translocation in Caco-2 cell monolayers or in colitis mice models. dextran sodium sulphate tight junction protein 1 Homo sapiens