Title : Endocannabinoids modulate Gq/11 protein-coupled receptor agonist-induced vasoconstriction via a negative feedback mechanism.

Pub. Date : 2018 Feb

PMID : 29148061






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The relationship between Gq/11 protein-coupled receptor activation, regulation of eCBs release (mainly 2-arachidonoylglycerol) and subsequent CB1 receptor activation was initially observed in the central nervous system. glyceryl 2-arachidonate cannabinoid receptor 1 Homo sapiens
2 KEY FINDINGS: Endocannabinoids (mainly 2-arachidonoylglycerol), acting via CB1 receptors, evoke vasodilatory effects and may modulate responses of vasoconstrictors for Gq/11 protein-coupled receptors including angiotensin II, thromboxane A2 , phenylephrine, noradrenaline in systemic or pulmonary arteries. glyceryl 2-arachidonate cannabinoid receptor 1 Homo sapiens