Title : Neuronal Loss in the Developing Cerebral Cortex of Normal and Bax-Deficient Mice: Effects of Ethanol Exposure.

Pub. Date : 2018 Jan 15

PMID : 29138110






3 Functional Relationships(s)
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1 The present study tested the hypothesis that ethanol exposure during the period of naturally occurring neuronal death causes a time- and Bax-dependent neuronal loss. Ethanol BCL2-associated X protein Mus musculus
2 Wild-type and Bax knockout mice were given a pair of injections (two hours apart) of ethanol (2.5 g/kg) or saline on postnatal day (P) 4, P7, P10, or P13. Ethanol BCL2-associated X protein Mus musculus
3 Thus, ethanol-induced death of cortical neurons is Bax-dependent, occurs concurrently in all layers, but does not correspond to lamina- and age-dependent expression of DNA fragmentation. Ethanol BCL2-associated X protein Mus musculus