Title : Crenolanib is a type I tyrosine kinase inhibitor that inhibits mutant KIT D816 isoforms prevalent in systemic mastocytosis and core binding factor leukemia.

Pub. Date : 2017 Oct 10

PMID : 29137311






1 Functional Relationships(s)
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1 Notably, crenolanib inhibits constitutively active mutant-FLT3 isoforms resulting from amino acid substitutions of aspartic acid at codon 835, which is homologous to codon 816 in the KIT gene - suggesting sensitivity against mutant-KIT D816 isoforms as well. Aspartic Acid fms related receptor tyrosine kinase 3 Homo sapiens