Title : Phospholipase D inhibitors reduce human prostate cancer cell proliferation and colony formation.

Pub. Date : 2018 Jan

PMID : 29136407






1 Functional Relationships(s)
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1 BACKGROUND: Phospholipases D1 and D2 (PLD1/2) hydrolyse cell membrane glycerophospholipids to generate phosphatidic acid, a signalling lipid, which regulates cell growth and cancer progression through effects on mTOR and PKB/Akt. Phosphatidic Acids mechanistic target of rapamycin kinase Homo sapiens