Pub. Date : 2018 Jan 15
PMID : 29129814
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The enhanced Cav3.2 activity by H2S formed by the upregulated cystathionine-gamma-lyase (CSE) is involved in the cyclophosphamide (CPA)-induced cystitis-related bladder pain in mice. | Cyclophosphamide | calcium channel, voltage-dependent, T type, alpha 1H subunit | Mus musculus |
| 2 | The enhanced Cav3.2 activity by H2S formed by the upregulated cystathionine-gamma-lyase (CSE) is involved in the cyclophosphamide (CPA)-induced cystitis-related bladder pain in mice. | Cyclophosphamide | calcium channel, voltage-dependent, T type, alpha 1H subunit | Mus musculus |
| 3 | Acute zinc deficiency caused by systemic N,N,N",N"-tetrakis-(2-pyridylmethyl)-ethylendiamine (TPEN), a zinc chelator, mimicked the dietary zinc deficiency-induced Cav3.2-dependent promotion of BP/RH following CPA at 200mg/kg. | Cyclophosphamide | calcium channel, voltage-dependent, T type, alpha 1H subunit | Mus musculus |
| 4 | CPA at 400mg/kg alone or TPEN plus CPA at 200mg/kg caused Cav3.2 overexpression accompanied by upregulation of Egr-1 and USP5, known to promote transcriptional expression and reduce proteasomal degradation of Cav3.2, respectively, in the dorsal root ganglia (DRG). | Cyclophosphamide | calcium channel, voltage-dependent, T type, alpha 1H subunit | Mus musculus |
| 5 | CPA at 400mg/kg alone or TPEN plus CPA at 200mg/kg caused Cav3.2 overexpression accompanied by upregulation of Egr-1 and USP5, known to promote transcriptional expression and reduce proteasomal degradation of Cav3.2, respectively, in the dorsal root ganglia (DRG). | Cyclophosphamide | calcium channel, voltage-dependent, T type, alpha 1H subunit | Mus musculus |
| 6 | CPA at 400mg/kg alone or TPEN plus CPA at 200mg/kg caused Cav3.2 overexpression accompanied by upregulation of Egr-1 and USP5, known to promote transcriptional expression and reduce proteasomal degradation of Cav3.2, respectively, in the dorsal root ganglia (DRG). | Cyclophosphamide | calcium channel, voltage-dependent, T type, alpha 1H subunit | Mus musculus |
| 7 | CPA at 400mg/kg alone or TPEN plus CPA at 200mg/kg caused Cav3.2 overexpression accompanied by upregulation of Egr-1 and USP5, known to promote transcriptional expression and reduce proteasomal degradation of Cav3.2, respectively, in the dorsal root ganglia (DRG). | Cyclophosphamide | calcium channel, voltage-dependent, T type, alpha 1H subunit | Mus musculus |
| 8 | The CSE inhibitor, beta-cyano-l-alanine, prevented the BP/RH and upregulation of Cav3.2, Egr-1 and USP5 in DRG following TPEN plus CPA at 200mg/kg. | Cyclophosphamide | calcium channel, voltage-dependent, T type, alpha 1H subunit | Mus musculus |
| 9 | Together, zinc deficiency promotes bladder pain accompanying CPA-induced cystitis by enhancing function and expression of Cav3.2 in nociceptors, suggesting a novel therapeutic avenue for treatment of bladder pain, such as zinc supplementation. | Cyclophosphamide | calcium channel, voltage-dependent, T type, alpha 1H subunit | Mus musculus |