Title : Purification and characterization of cytochrome P-450 induced by benz(a)anthracene in mouse skin microsomes.

Pub. Date : 1989 Feb 15

PMID : 2912553






3 Functional Relationships(s)
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1 Purification and characterization of cytochrome P-450 induced by benz(a)anthracene in mouse skin microsomes. benz(a)anthracene cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus
2 Topical application of benz(a)anthracene to mouse skin elicited a 2-fold increase in cytochrome P-450 content, with accompanying increases in monooxygenase activities such as benzo(a)pyrene hydroxylation, 7-ethoxycoumarin O-deethylation, and acetanilide 4-hydroxylation, in the microsomes. benz(a)anthracene cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus
3 The results indicate that, in mouse skin microsomes, a cytochrome P-450 induced by benz(a)anthracene is enzymatically and immunochemically similar to rat liver cytochrome P-450MC-1. benz(a)anthracene cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus