Pub. Date : 2015 Jul
PMID : 29124159
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In an attempt to examine that possibility, we could successfully find that human organic cation transporter 1 (OCT1/SLC22A1), which is suggested to be expressed at the brush border membrane of enterocytes, is highly capable of transporting atenolol. | Atenolol | solute carrier family 22 member 1 | Homo sapiens |
| 2 | In an attempt to examine that possibility, we could successfully find that human organic cation transporter 1 (OCT1/SLC22A1), which is suggested to be expressed at the brush border membrane of enterocytes, is highly capable of transporting atenolol. | Atenolol | solute carrier family 22 member 1 | Homo sapiens |
| 3 | In an attempt to examine that possibility, we could successfully find that human organic cation transporter 1 (OCT1/SLC22A1), which is suggested to be expressed at the brush border membrane of enterocytes, is highly capable of transporting atenolol. | Atenolol | solute carrier family 22 member 1 | Homo sapiens |
| 4 | Particularly, phloretin and quercetin, which are major components of apple juice, were potent in inhibiting OCT1-mediated atenolol transport with the inhibition constants of 38.0 and 48.0 microM, respectively. | Atenolol | solute carrier family 22 member 1 | Homo sapiens |
| 5 | These results indicate that OCT1 is an atenolol transporter that may be involved in intestinal atenolol uptake and sensitive to fruit juices, although its physiological and clinical relevance remains to be further examined. | Atenolol | solute carrier family 22 member 1 | Homo sapiens |