Title : Lunasin functionally enhances LDL uptake via inhibiting PCSK9 and enhancing LDLR expression in vitro and in vivo.

Pub. Date : 2017 Oct 6

PMID : 29113347






1 Functional Relationships(s)
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1 Taken together, our findings suggest that lunasin inhibits PCSK9 expression by down-regulating HNF-1alpha and enhances LDLR expression via PI3K/Akt-mediated activation of SREBP-2 pathway, thereby functionally enhances LDL uptake in HepG2 cells and in ApoE-/- mice. LUNASINE apolipoprotein E Homo sapiens