Pub. Date : 2018 Jan 5
PMID : 29108775
1 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | SK-N-SH cell treatment with a lethal concentration of PQ facilitated ROS production within 6 h. The treatment also promoted formation of 8-hydroxy-deoxyguanosine, p53 activation, elevation of Bax/Bcl-2 ratio, lowering of mitochondrial membrane potential, and resultant activation of caspase-9 and caspase-3, inferring that ROS production, DNA damage and mitochondrial dysfunction are crucial processes of the PQ-triggered SK-N-SH cell apoptosis. | sk-n | tumor protein p53 | Homo sapiens |