PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29108775-3 2018 SK-N-SH cell treatment with a lethal concentration of PQ facilitated ROS production within 6 h. The treatment also promoted formation of 8-hydroxy-deoxyguanosine, p53 activation, elevation of Bax/Bcl-2 ratio, lowering of mitochondrial membrane potential, and resultant activation of caspase-9 and caspase-3, inferring that ROS production, DNA damage and mitochondrial dysfunction are crucial processes of the PQ-triggered SK-N-SH cell apoptosis. sk-n 0-4 tumor protein p53 Homo sapiens 163-166