Title : Chronic treatment with caffeine and its withdrawal modify the antidepressant-like activity of selective serotonin reuptake inhibitors in the forced swim and tail suspension tests in mice. Effects on Comt, Slc6a15 and Adora1 gene expression.

Pub. Date : 2017 Dec 15

PMID : 29107002






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Caffeine withdrawal caused a decrease in Adora1 mRNA level in the cerebral cortex (Cx). Caffeine adenosine A1 receptor Mus musculus
2 Administration of escitalopram or fluoxetine followed by caffeine withdrawal caused an increase in this gene expression, whereas administration of escitalopram, but not fluoxetine, on day 15th together with caffeine caused a decrease in Adora1 mRNA level in the Cx. Caffeine adenosine A1 receptor Mus musculus