Title : Effect of TALEN-mediated IL-6 knockout on cell proliferation, apoptosis, invasion and anti-cancer therapy in hepatocellular carcinoma (HCC-LM3) cells.

Pub. Date : 2017 Sep 29

PMID : 29100435






4 Functional Relationships(s)
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1 Experimental Design: IL-6 was disrupted by transcription activator-like effector nucleases (TALEN) in HCCLM3 cells, and was used to evaluate the role of IL-6 on tumor cell proliferation, apoptosis, invasion and key signaling pathways involved in sorafenib and/or IFNalpha therapy. Sorafenib interleukin 6 Homo sapiens
2 IL-6 could attenuate the anti-proliferation effect by sorafenib and combination therapy but facilitate the pro-apoptosis of the combination therapy and augment the pro-invasive effect induced by single treatment. Sorafenib interleukin 6 Homo sapiens
3 IL-6 could down-regulate p-STAT3, however up-regulate the p-MEK/p-ERK and NF-kB/iNOS expression, and it also facilitated the promotion on p-JAK2 and p-MEK/p-ERK by either sorafenib or IFN-alpha. Sorafenib interleukin 6 Homo sapiens
4 Sorafenib and combination therapies are suitable for HCC cells with low or no IL-6 expression confirmed in vivo study. Sorafenib interleukin 6 Homo sapiens