Title : Nicotine induces EP4 receptor expression in lung carcinoma cells by acting on AP-2α: The intersection between cholinergic and prostanoid signaling.

Pub. Date : 2017 Sep 29

PMID : 29100274






3 Functional Relationships(s)
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1 Nicotine induces EP4 receptor expression in lung carcinoma cells by acting on AP-2alpha: The intersection between cholinergic and prostanoid signaling. Nicotine transcription factor AP-2 alpha Homo sapiens
2 We evaluated whether nicotine increased EP4 receptor expression in lung carcinoma cells by activating on AP-2alpha. Nicotine transcription factor AP-2 alpha Homo sapiens
3 It indicates that nicotine increases EP4 expression through alpha7 nicotinic acetylcholine receptor-dependent activations of PI3-K, JNK and PKC pathways that leads to reduction of AP-2alpha-DNA binding. Nicotine transcription factor AP-2 alpha Homo sapiens