Title : Bisphenol AF as an Inducer of Estrogen Receptor β (ERβ): Evidence for Anti-estrogenic Effects at Higher Concentrations in Human Breast Cancer Cells.

Pub. Date : 2017

PMID : 29093337






4 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Among these bisphenols, BPAF up-regulated the expression of ERbeta, and this was coupled with the abrogation of estrogen response element (ERE)-mediated transcriptional activities as well as the down-regulation of Cdc2 expression in MCF-7 cells, without influencing the expression of ERalpha. 4,4'-hexafluorisopropylidene diphenol estrogen receptor 2 Homo sapiens
2 The introduction of ERbeta cDNA resulted in greater reductions in MCF-7 cell viability than with BPAF alone. 4,4'-hexafluorisopropylidene diphenol estrogen receptor 2 Homo sapiens
3 Since ERbeta is a suppressive molecule of ERalpha function, these results provide rational evidence for BPAF functioning as an anti-estrogenic compound via the induction of ERbeta at higher concentrations. 4,4'-hexafluorisopropylidene diphenol estrogen receptor 2 Homo sapiens
4 Since ERbeta is a suppressive molecule of ERalpha function, these results provide rational evidence for BPAF functioning as an anti-estrogenic compound via the induction of ERbeta at higher concentrations. 4,4'-hexafluorisopropylidene diphenol estrogen receptor 2 Homo sapiens