Protein Name estrogen receptor 2
Organism Homo sapiens
Gene ID 2100
Gene Symbol


UniProt Q92731 (ESR2_HUMAN), F1D8N3 (F1D8N3_HUMAN), Q7LCB3 (Q7LCB3_HUMAN), A0A348FV93 (A0A348FV93_HUMAN), Q0PTK2 (Q0PTK2_HUMAN)
Relationships Total Number of functionally related compound(s) : 856
Total Number of Articles : 1374

estrogen receptor 2

Gene Summary

This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. [provided by RefSeq, Jul 2008]

  • estrogen receptor beta
  • estrogen receptor beta 2
  • estrogen receptor beta 4
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