Title : Organic Cation Transporter 1 Is Responsible for Hepatocellular Uptake of the Tyrosine Kinase Inhibitor Pazopanib.

Pub. Date : 2018 Jan

PMID : 29089306






3 Functional Relationships(s)
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1 Importantly, OCT1-mediated uptake of a typical OCT1 substrate metformin was inhibited by pazopanib with an IC50 value of 0.253 microM, indicating that pazopanib has the potential for clinically relevant inhibition of human OCT1. Metformin solute carrier family 22 member 1 Homo sapiens
2 Importantly, OCT1-mediated uptake of a typical OCT1 substrate metformin was inhibited by pazopanib with an IC50 value of 0.253 microM, indicating that pazopanib has the potential for clinically relevant inhibition of human OCT1. Metformin solute carrier family 22 member 1 Homo sapiens
3 Importantly, OCT1-mediated uptake of a typical OCT1 substrate metformin was inhibited by pazopanib with an IC50 value of 0.253 microM, indicating that pazopanib has the potential for clinically relevant inhibition of human OCT1. Metformin solute carrier family 22 member 1 Homo sapiens