Pub. Date : 2017 Sep 26
PMID : 29088845
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Nicotine suppresses apoptosis by regulating alpha7nAChR/Prx1 axis in oral precancerous lesions. | Nicotine | cholinergic receptor, nicotinic, alpha polypeptide 7 | Mus musculus |
| 2 | In DOK cells, Prx1 knockdown and blocking alpha7nAChR activated apoptosis, and nicotine increased the expression of Prx1, alpha3nAChR and alpha7nAChR, and inhibited MAPK activation. | Nicotine | cholinergic receptor, nicotinic, alpha polypeptide 7 | Mus musculus |
| 3 | Moreover, nicotine suppressed apoptosis depending on Prx1 and alpha7nAChR in DOK cells. | Nicotine | cholinergic receptor, nicotinic, alpha polypeptide 7 | Mus musculus |
| 4 | Our data demonstrate that nicotine inhibits cell apoptosis and promotes the growth of oral precancerous lesions via regulating alpha7nAChR/Prx1 during carcinogenesis of OSCC. | Nicotine | cholinergic receptor, nicotinic, alpha polypeptide 7 | Mus musculus |