Title : Long-term administration of ketamine induces erectile dysfunction by decreasing neuronal nitric oxide synthase on cavernous nerve and increasing corporal smooth muscle cell apoptosis in rats.

Pub. Date : 2017 Sep 26

PMID : 29088735






2 Functional Relationships(s)
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1 In the erectile tissue, ketamine administration significantly reduced nNOS expression and increased iNOS content compared with controls, whereas eNOS expression was not altered. Ketamine nitric oxide synthase 2 Rattus norvegicus
2 The molecular mechanisms of ketamine-induced ED involved the increased apoptosis and up-regulated iNOS expression incorporating with loss of corporal smooth muscle content and reduced nNOS expression in cavernous nerve. Ketamine nitric oxide synthase 2 Rattus norvegicus