Pub. Date : 2018 Jun
PMID : 29086249
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We firstly inhibited eIF4E activity by ribavirin in two cell lines (Caki-1 and ACHN) representing RCC metastasis models. | Ribavirin | eukaryotic translation initiation factor 4E | Homo sapiens |
| 2 | We further confirmed that the inhibitory effects of ribavirin were attributed to its ability in inhibiting eIF4E-regulated protein translation and activity. | Ribavirin | eukaryotic translation initiation factor 4E | Homo sapiens |
| 3 | eIF4E inhibition using siRNA knockdown mimicked ribavirin"s effector in RCC cells. | Ribavirin | eukaryotic translation initiation factor 4E | Homo sapiens |
| 4 | Importantly, eIF4E inhibition by both ribavirin and siRNA knockdown significantly sensitized RCC response to chemo- and immunotherapeutic agents in vitro as well as in vivo. | Ribavirin | eukaryotic translation initiation factor 4E | Homo sapiens |