Title : Reversal of doxorubicin-resistance by Salvia miltiorrhiza ligustrazine in the SHG44/doxorubicin glioma drug-resistant cell line.

Pub. Date : 2017 Oct

PMID : 29085470






2 Functional Relationships(s)
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1 The SHG44/DOX cells grew continually in 0.1 microg/ml DOX and expressed increased levels of mRNA of multidrug resistance genes [multidrug resistance 1 (MDR1), multidrug resistance-associated protein 1 (MRP1) and lung resistance protein (LRP)] compared with the parental SHG44 cells. Doxorubicin major vault protein Homo sapiens
2 In addition, the levels of MDR1, MRP1 and LRP were downregulated by this traditional Chinese medicine, coupled with increased intracellular DOX concentrations. Doxorubicin major vault protein Homo sapiens