Protein Name major vault protein
Organism Homo sapiens
Gene ID 9961
Gene Symbol


UniProt Q14764 (MVP_HUMAN), X5D2M8 (X5D2M8_HUMAN), X5D7K9 (X5D7K9_HUMAN), X5DNU0 (X5DNU0_HUMAN)
Relationships Total Number of functionally related compound(s) : 105
Total Number of Articles : 145

major vault protein

Gene Summary

This gene encodes the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that may be involved in nucleo-cytoplasmic transport. The encoded protein may play a role in multiple cellular processes by regulating the MAP kinase, JAK/STAT and phosphoinositide 3-kinase/Akt signaling pathways. The encoded protein also plays a role in multidrug resistance, and expression of this gene may be a prognostic marker for several types of cancer. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]

  • major vault protein
  • lung resistance-related protein
  • testicular secretory protein Li 30
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